Diagnostics Accelerator Expands Its Investments in Digital Biomarkers for Early Alzheimer's Disease. The four new research investments for technology-based biomarkers will help identify subtle, yet pertinent psychological and behavioral changes that happen very early in people with Alzheimer’s but may go unnoticed Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of the elderly and is characterized by regional specificity of neural aberrations associated with higher cognitive functions. Aluminum (Al) is the most abundant neurotoxic metal on earth, widely bioavailable to humans and repeatedly shown to accumulate in AD-susceptible Jun 07, · "Research for Alzheimer's disease and other dementias is significantly under-funded when compared to other diseases. There is an urgent need to invest in dementia research
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The brain is a highly compartmentalized organ alzheimers research paper susceptible to accumulation of metabolic errors. Alzheimer's disease AD is the most prevalent neurodegenerative disease of the elderly and is characterized by regional specificity of neural aberrations associated with higher cognitive functions. Aluminum Al is the most abundant neurotoxic metal on earth, widely bioavailable to humans and repeatedly shown to accumulate in AD-susceptible neuronal foci.
In spite of this, the role of Al in AD has been heavily disputed based on the following claims: 1 bioavailable Al cannot enter the brain in sufficient amounts to cause damage, 2 excess Al is efficiently excreted from the body, alzheimers research paper, and 3 Al accumulation in neurons is a consequence rather than a cause of neuronal loss.
Research, however, reveals that: 1 very small amounts of Al are needed to produce neurotoxicity and this criterion is satisfied through dietary Al intake, alzheimers research paper, alzheimers research paper Al sequesters different transport mechanisms to actively traverse brain barriers, 3 incremental acquisition of small amounts of Al over a lifetime favors its selective accumulation in brain tissues, and 4 sinceexperimental evidence has repeatedly demonstrated that chronic Al intoxication reproduces neuropathological hallmarks of Alzheimers research paper. Misconceptions about Al bioavailability may have misled scientists regarding the significance of Al in the pathogenesis of AD.
The hypothesis that Al significantly contributes to AD is built upon very solid experimental evidence and should not be dismissed. Immediate steps should be taken to lessen human exposure to Al, which may be the single most aggravating and avoidable factor related to AD.
Abstract The brain is a highly compartmentalized organ exceptionally susceptible to accumulation of metabolic errors. Publication types Review.
Substances Aluminum.
Dr. Kim Green discusses critical new discovery in Alzheimer’s research with CBS News
, time: 4:25Aluminum and Alzheimer's disease: after a century of controversy, is there a plausible link?
Diagnostics Accelerator Expands Its Investments in Digital Biomarkers for Early Alzheimer's Disease. The four new research investments for technology-based biomarkers will help identify subtle, yet pertinent psychological and behavioral changes that happen very early in people with Alzheimer’s but may go unnoticed May 05, · The research paper in Molecular Neurodegeneration adds that the test’s “excellent performance” for Alzheimer’s disease (AD) diagnosis allows for “improved medical decision making and Alzheimer’s Disease/Dementia and Caregivers- Alzheimer’s Disease research papers look at an example of how to order a Master’s Level Thesis. Blood Test for Alzheimer’s - The pursuit of a test to help diagnose a patient for Alzheimer’s disease has been ongoing for more than 2 decades however scientists are closer than ever in meeting
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